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Click HERE to request reprints or licensing information. DNA Diagnostics Atom Sciences is currently involved with several research projects to develop improved DNA diagnostics. The common thread throughout these projects is the use of DNA arrays. DNA arrays (also known as DNA microarrays, genosensor chips, or DNA chips) are typically made up of arrays of single-stranded DNA segments bound to a solid substrate. The identification of genetic information (i.e. the existence of specific nucleotide sequences) in target DNA is based upon complementary hybridization of the unknown target DNA with probes of known sequence at specific sites on the array. Detailed information on DNA arrays can be obtained in the chapter on DNA Arrays; Preparation and Application in the Clinical Chemistry section of the Encyclopedia of Analytical Chemistry published by John Wiley and Sons, Ltd. This chapter, written by Dr. Tom J. Whitaker (President of Atom Sciences), Dr. K. Bruce Jacobson (Atom Sciences), and Dr. Mitch Doktycz (Oak Ridge National Laboratory), describes the factors that must be considered in designing and preparing DNA probes for specific applications. Active or Recent DNA Research at Atom Sciences Limited Primer Extension (LPE) Diagnostic for Members of Genus Mycobacterium
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